Kinetics of release of antiretroviral drugs through a silicone intravaginal ring
نویسندگان
چکیده
Aim The propagation of HIV-1 infection represents a major problem of public health, notably in sub-Saharan Africa where about six out of ten infected adults are women. Among the new options of preventive therapy, antiretroviral drugs used as microbicides distributed via an intravaginal ring (IVR) constitutes an original solution. IVR is an interesting mode of drug delivery because it is a coit-independent device that can be left in the vagina for several months and can release regular amounts of microbicides. The aim of this work was to set up a silicone IVR able to deliver simultaneously several drugs with the precise objective of determining if the release of each drug is possible with the used silicones and of choosing the best formulation.
منابع مشابه
Development and in vitro/in vivo Evaluation of a Silastic Intravaginal Ring for Mifepristone Delivery
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